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Search Results for " Phosphoinositide 3-kinase "

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136

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T4219	Autophinib		PI3K , Autophagy
	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.		PI3K , Autophagy
T9460	IMDK		PI3K
	iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou...		PI3K
T2672	TG100-115		PI3K
	TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.		PI3K
T2418	A66		PI3K
	A66 is a specific and effective p110α inhibitor(IC50=32 nM).		PI3K
T15592	IPI-3063		PI3K
	IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).		PI3K
T6757	AMG319		PI3K
	AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.		PI3K
T6208	AS-252424		Casein Kinase , PI3K
	AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.		Casein Kinase , PI3K
T2619	CH5132799		PI3K , mTOR
	CH5132799 has been used in trials studying the treatment of Solid Tumors.		PI3K , mTOR
T22377	NIBR-17		PI3K
	NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.		PI3K
TQ0229	ETP-46321		PI3K
	ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).		PI3K
T1949	CZC24832		PI3K
	CZC24832 is a selective inhibitor of PI 3-kinase γ.		PI3K
T6773	AZD8186		PI3K
	AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).		PI3K
T13386	Zandelisib		PI3K
	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.		PI3K
T2661	TGX-221	TGX221	PI3K
	TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.		PI3K
T3348	PIK-293	PIK293	PI3K
	PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.		PI3K
T6168	ZSTK474		PI3K , Autophagy
	PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.		PI3K , Autophagy
T6433	CAY10505		Apoptosis , PI3K
	CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).		Apoptosis , PI3K
T2461	PIK-90		DNA-PK , PI3K
	PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .		DNA-PK , PI3K
T2083	PI-3065	PI3065	DNA-PK , PI3K , mTOR
	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.		DNA-PK , PI3K , mTOR
T2297	PIK-294	PIK294	PI3K
	PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).		PI3K
T6774	AZD-8835	AZD8835	PI3K
	AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).		PI3K
T12831L	SAR405		PI3K , Autophagy
	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by sta...		PI3K , Autophagy
T8461	SKI V		Apoptosis , PI3K , S1P Receptor
	SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity		Apoptosis , PI3K , S1P Receptor
T2660	IC-87114	IC 87114	PI3K
	IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).		PI3K
T6799	IITZ-01		Apoptosis , PI3K , Autophagy
	IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)		Apoptosis , PI3K , Autophagy
T3985	GDC-0326	GDC 0326,GDC0326	PI3K
	GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).		PI3K
T6938	PF-4989216	PF 4989216	Apoptosis , PI3K
	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.		Apoptosis , PI3K
T5166	Leniolisib	CDZ173	DNA-PK , PI3K
	Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).		DNA-PK , PI3K
T13862	Recilisib	Ex-RAD,ON 01210	Akt , PI3K
	Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.		Akt , PI3K
T3986	SF2523		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
	SF2523 is a highly selective and potent inhibitor.		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
T13119	Tenalisib	RP6530	PI3K
	Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)		PI3K
TQ0044	Seletalisib	UCB5857	PI3K
	Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).		PI3K
T14944	CGS 15943		PI3K , Adenosine Receptor
	CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively.		PI3K , Adenosine Receptor
T2073	GSK2636771	GSK 2636771,GSK-2636771	PI3K
	GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.		PI3K
T2308	HS-173	HS 173,HS173	Apoptosis , PI3K
	HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).		Apoptosis , PI3K
T4296	MTX-211	MTX 211	EGFR , PI3K
	MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.		EGFR , PI3K
T7879	TASP0415914		Akt , PI3K
	TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T		Akt , PI3K
T5432	Eganelisib	IPI-549	PI3K
	Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)		PI3K
T13376	YS-49		RAAS , Akt , PI3K , Adrenergic Receptor
	YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).		RAAS , Akt , PI3K , Adrenergic Receptor
T28416	PIK-108	PIK 108,PIK108	PI3K
	PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).		PI3K
T7343	PF-04979064		PI3K , mTOR
	PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).		PI3K , mTOR
T7166	GNE-493		PI3K , mTOR
	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.		PI3K , mTOR
T16355	NSC781406		PI3K , mTOR
	NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).		PI3K , mTOR
T6557	KU-0060648	KU0060648	DNA-PK , PI3K , mTOR
	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.		DNA-PK , PI3K , mTOR
T6110	YM-201636		Influenza Virus , PI3K , Autophagy
	YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.		Influenza Virus , PI3K , Autophagy
T12115	MSC2360844		PI3K
			PI3K
T6845	GNE-317	GNE317	PI3K , mTOR
	GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).		PI3K , mTOR
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T6704	TG 100713	TG100713	PI3K
	TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.		PI3K
T21938	AS-041164		PI3K
	AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory e...		PI3K

Compounds

Autophinib

T4219

Synonym:

Target: PI3K, Autophagy

Target: Casein Kinase, PI3K

Target: PI3K, Autophagy

CAY10505

T6433

Synonym:

Target: Apoptosis, PI3K

Target: DNA-PK, PI3K, mTOR

Target: PI3K, Autophagy

SKI V

T8461

Synonym:

Target: Apoptosis, PI3K, S1P Receptor

Target: Apoptosis, PI3K, Autophagy

GDC-0326

T3985

Synonym: GDC 0326,GDC0326

Target: Apoptosis, PI3K

Synonym: Ex-RAD,ON 01210

Target: DNA-PK, Epigenetic Reader Domain, PI3K, mTOR

Target: PI3K, Adenosine Receptor

GSK2636771

T2073

Synonym: GSK 2636771,GSK-2636771

Target: PI3K

HS-173

T2308

Synonym: HS 173,HS173

Target: Apoptosis, PI3K

Target: RAAS, Akt, PI3K, Adrenergic Receptor

PIK-108

T28416

Synonym: PIK 108,PIK108

Target: DNA-PK, PI3K, mTOR

YM-201636

T6110

Synonym:

Target: Influenza Virus, PI3K, Autophagy

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

カタログ番号	製品名	別名	ターゲット
T4S1796	Heterophyllin B		PI3K
	Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa...		PI3K
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
TN1134	Euscaphic acid		Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor
	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of...
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
TN4673	(+)-Nortrachelogenin	Wikstromol	Apoptosis , HIV Protease , PI3K , Antifection
	(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.		Apoptosis , HIV Protease , PI3K , Antifection
T6630	Quercetin Dihydrate	Sophoretin	Apoptosis , PI3K
	Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effect...		Apoptosis , PI3K
T5654	Musk ketone		Others
	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.		Others
T2174	Quercetin	Sophoretin	Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
T2798	Esculetin	Aesculetin,Cichorigenin	Lipoxygenase , Akt , PI3K
	Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip...		Lipoxygenase , Akt , PI3K
T1879	3-Methyladenine	3-MA,NSC 66389	Mitophagy , PI3K , Endogenous Metabolite , Autophagy
	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.		Mitophagy , PI3K , Endogenous Metabolite , Autophagy
T2746	Sophocarpine monohydrate	Sophocarpine	Apoptosis , Influenza Virus , Akt , PI3K , AMPK , Autophagy
	Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		Apoptosis , Influenza Virus , Akt , PI3K , AMPK , Autophagy
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
T3780	Oroxin B	Hypocretin-2	Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
	Oroxin B (Hypocretin-2) has antioxidant activity.		Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
TN1299	Desmethylglycitein	6,7,4'-Trihydroxyisoflavone	PI3K , CDK , PKC
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.		PI3K , CDK , PKC
T4867	Erucic acid	Prifac 2990,13(Z)-Docosenoic Acid,cis-13-docosenoic acid	PI3K , Endogenous Metabolite
	Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain...		PI3K , Endogenous Metabolite
T5740	25(R,S)-Ruscogenin	(25RS)-Ruscogenin	Others , HIF
	25(R,S)-Ruscogenin is a natual product.		Others , HIF
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
T3675	1-Deoxynojirimycin	Duvoglustat,Moranoline,moranolin	PI3K , Glucosidase
	1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.		PI3K , Glucosidase
T3P2904	α-Linolenic acid	Alpha-Linolenic Acid,Linolenic acid	Akt , PI3K
	α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostagland...		Akt , PI3K
T5736	1,3-Dicaffeoylquinic acid	CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid	Reactive Oxygen Species , Akt , PI3K
	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.		Reactive Oxygen Species , Akt , PI3K
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T3208	Brevianamide F	Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP , PI3K , Antibacterial
	Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess interesting breast cancer resistance protein inhibitory acti...		BCRP , PI3K , Antibacterial
T21344	1-Deoxynojirimycin hydrochloride	Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K , Antibacterial , Antibiotic , Glucosidase
	1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.		PI3K , Antibacterial , Antibiotic , Glucosidase
T4S1499	Ginsenoside Rk1		Apoptosis , Others , NF-κB , PI3K , JAK
	Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB. It also h...		Apoptosis , Others , NF-κB , PI3K , JAK
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine	(4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine	PI3K
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secr...		PI3K
T73812	Phosphatidylinositol 4,5-bisphosphate
	Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate), serving as a critical phospholipid in cell membranes, functions as a substrate for both phospholipase C (PLC) and phosphoinositide 3-...
TN5050	Sprengerinin C		NADPH-oxidase , VEGFR , p38 MAPK , ROS , Akt , PI3K , mTOR , p53
	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein ...

天然物製品

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Euscaphic acid

TN1134

Synonym:

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

(+)-Nortrachelogenin

TN4673

Synonym: Wikstromol

Target: Apoptosis, HIV Protease, PI3K, Antifection

Quercetin Dihydrate

T6630

Synonym: Sophoretin

Target: Apoptosis, PI3K

Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy

Esculetin

T2798

Synonym: Aesculetin,Cichorigenin

Target: Lipoxygenase, Akt, PI3K

3-Methyladenine

T1879

Synonym: 3-MA,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Sophocarpine monohydrate

T2746

Synonym: Sophocarpine

Target: Apoptosis, Influenza Virus, Akt, PI3K, AMPK, Autophagy

Orobol

TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon

Target: BCL, Caspase, PI3K

Glaucocalyxin A

T4S0498

Synonym: Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Arnicolide D

TN1405

Synonym:

Target: Akt, Caspase, PI3K, STAT, mTOR

Polygalasaponin F

T3826

Synonym:

Target: NF-κB, TLR, Akt, PI3K

Oroxin B

T3780

Synonym: Hypocretin-2

Target: Apoptosis, PTEN, Antioxidant, PI3K, Autophagy

Desmethylglycitein

TN1299

Synonym: 6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Erucic acid

T4867

Synonym: Prifac 2990,13(Z)-Docosenoic Acid,cis-13-docosenoic acid

Target: PI3K, Endogenous Metabolite

25(R,S)-Ruscogenin

T5740

Synonym: (25RS)-Ruscogenin

Target: Others, HIF

Hederacolchiside A1

T2P2806

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

1-Deoxynojirimycin

T3675

Synonym: Duvoglustat,Moranoline,moranolin

Target: PI3K, Glucosidase

α-Linolenic acid

T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid

Target: Akt, PI3K

1,3-Dicaffeoylquinic acid

T5736

Synonym: CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid

Target: Reactive Oxygen Species, Akt, PI3K

Dihydrocapsaicin

T2163

Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Brevianamide F

T3208

Synonym: Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)

Target: BCRP, PI3K, Antibacterial

1-Deoxynojirimycin hydrochloride

T21344

Synonym: Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

Target: PI3K, Antibacterial, Antibiotic, Glucosidase

Ginsenoside Rk1

T4S1499

Synonym:

Target: Apoptosis, Others, NF-κB, PI3K, JAK

(2S,3R,4S)-4-Hydroxyisoleucine

T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,Hydroxyisoleucine

Target: PI3K

Phosphatidylinositol 4,5-bisphosphate

Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03111	PIK3IP1 Protein, Human, Recombinant (hFc)	Human	HEK293
	PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, me...
TMPY-04933	PIK3IP1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, me...
TMPJ-01271	PIK3IP1 Protein, Human, Recombinant (His)	Human	Human Cells
	Phosphoinositide-3-kinase-interacting protein 1(PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.It is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepato...
TMPY-02758	ENTPD5 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed ...
TMPY-04276	ENTPD5 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed ...
TMPY-04574	AKT3 Protein, Mouse, Recombinant (aa 106-479, His & GST)	Mouse	Baculovirus-Insect Cells
	v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as...
TMPY-04446	AKT3 Protein, Mouse, Recombinant (aa 106-479)	Mouse	Baculovirus-Insect Cells
	v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as...
TMPY-04553	AKT3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as...
TMPH-01719	OPRM1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to th...
TMPH-01857	PIK3CG Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-contai...
TMPY-02910	Nicastrin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-01297	Nicastrin Protein, Human, Recombinant (His)	Human	HEK293
	Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-03074	Nicastrin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-06986	FGF-8b Protein, Human, Recombinant	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His)	Human	HEK293
	NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylph...
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc)	Human	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPY-00132	Mesothelin Protein, Human, Recombinant	Human	HEK293
	The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glyc...
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-03763	Neuropilin-2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac...
TMPY-00892	Neuropilin-2 Protein, Human, Recombinant (His)	Human	HEK293
	Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation fac...
TMPY-04683	CD47 Protein, Human, Recombinant	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-01897	PRSS3 Protein, Human, Recombinant (His)	Human	HEK293
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains on...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His)	Human	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-01180	CD86 Protein, Human, Recombinant (His)	Human	HEK293
	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co...
TMPY-04298	CDCP1 Protein, Human, Recombinant (His)	Human	HEK293
	CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, ...
TMPY-00480	NCAM1 Protein, Human, Recombinant (His)	Human	HEK293
	NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli...
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc)（Human Cells）	Human	Human Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bi...
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His)	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-00072	GITR/TNFRSF18 Protein, Human, Recombinant (His)	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)...
TMPJ-00390	FGFR2IIIb Protein, Human, Recombinant (hFc)	Human	Human Cells
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-04157	RANK/TNFRSF11A Protein, Human, Recombinant (His)	Human	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small i...
TMPY-03883	CD47 Protein, Human, Recombinant (hFc)	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a mem...
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger...
TMPY-01656	VEGF183 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPK-00399	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region c...
TMPK-00447	CD45 Protein, Human, Recombinant (aa 26-577, hFc)	Human	HEK293
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPJ-00899	HER3/ERBB3 Protein, Human, Recombinant (aa 20-331, hFc)	Human	Human Cells
	Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belon...
TMPY-05590	NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli...
TMPY-05383	NKp30/NCR3 Protein, Human, Recombinant (hFc)	Human	HEK293
	Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and...
TMPY-03969	SUSD4 Protein, Human, Recombinant (mFc)	Human	HEK293
	SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and ...
TMPY-06411	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)...
TMPY-04273	FGFR2 Protein, Human, Recombinant (aa 1-378, His)	Human	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-04386	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)	Human	Baculovirus-Insect Cells
	Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPJ-00054	PLGF-2 Protein, Human, Recombinant (His)	Human	Human Cells
	Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF f...
TMPY-03435	NCKIPSD Protein, Human, Recombinant (GST)	Human	E. coli
	NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an importa...
TMPY-05246	CD86 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co...
TMPY-03621	EphB2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-02691	IL-17RC Protein, Human, Recombinant(aa 1-454, hFc)	Human	HEK293
	IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). IL17RC is widely expressed in the pr...
TMPY-00276	PLGF/PGF Protein, Human, Recombinant (mFc)	Human	HEK293
	PLGF/PGF Protein, Human, Recombinant (mFc) is expressed in HEK293 with mFc tag. The predicted molecular weight is 43.7 kDa. Accession number: P49763-3
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